HCO(-3)-dependent pHi recovery and overacidification induced by NH+4 pulse in rat lung alveolar type II cells: HCO(-3)-dependent NH3 excretion from lungs?

@article{Tokuda2007HCO3dependentPR,
  title={HCO(-3)-dependent pHi recovery and overacidification induced by NH+4 pulse in rat lung alveolar type II cells: HCO(-3)-dependent NH3 excretion from lungs?},
  author={Sachiko Tokuda and Chikao Shimamoto and Hideyo Yoshida and Hitoshi Murao and Gen-ichi Kishima and Shigenori Ito and Takahiro Kubota and Toshiaki Hanafusa and Tohru Sugimoto and Naomi Niisato and Yoshinori Marunaka and Takashi Nakahari},
  journal={Pflugers Archiv : European journal of physiology},
  year={2007},
  volume={455 2},
  pages={223-39}
}
Intracellular pH (pHi) after the NH+4 pulse addition and its removal were measured in isolated alveolar type II cells (ATII cells) using BCECF fluorescence. In the absence of HCO(-3), the NH+4 pulse addition increased pHi (alkali jump) and its removal decreased pH(i) (acid jump) to the control level (no overacidification). This pHi change was induced by reaction 1 (NH3 + H+ <--> NH+4). However, in the presence of HCO(-3), the NH+4 pulse removal decreased pHi (acid jump) with overacidification… CONTINUE READING

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