HCN channels expressed in the inner ear are necessary for normal balance function.

@article{Horwitz2011HCNCE,
  title={HCN channels expressed in the inner ear are necessary for normal balance function.},
  author={Geoffrey C. Horwitz and Jessica R. Risner-Janiczek and Sherri M Jones and Jeffrey R. Holt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 46},
  pages={16814-25}
}
HCN1-4 subunits form Na+/K+-permeable ion channels that are activated by hyperpolarization and carry the current known as I(h). I(h) has been characterized in vestibular hair cells of the inner ear, but its molecular correlates and functional contributions have not been elucidated. We examined Hcn mRNA expression and immunolocalization of HCN protein in the mouse utricle, a mechanosensitive organ that contributes to the sense of balance. We found that HCN1 is the most highly expressed subunit… CONTINUE READING
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