HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition

Abstract

Hyperpolarization- and cyclic nucleotide-activated (HCN) channels contribute to rhythmic oscillations in excitable cells. They possess an intrinsic autoinhibition with a hyperpolarized V 1/2, which can be relieved by cAMP binding to the cyclic nucleotide binding (CNB) fold in the C-terminal region or by deletion of the CNB fold. We questioned whether V 1/2… (More)
DOI: 10.1007/s00232-015-9816-7

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