HCN: A plausible source of purines, pyrimidines and amino acids on the primitive earth

@article{Ferris2005HCNAP,
  title={HCN: A plausible source of purines, pyrimidines and amino acids on the primitive earth},
  author={J. Ferris and P. Joshi and E. Edelson and J. Lawless},
  journal={Journal of Molecular Evolution},
  year={2005},
  volume={11},
  pages={293-311}
}
  • J. Ferris, P. Joshi, +1 author J. Lawless
  • Published 2005
  • Biology, Medicine
  • Journal of Molecular Evolution
  • SummaryDilute (0.1M) solutions of HCN condense to oligomers at pH 9.2. Hydrolysis of these oligomers yields 4,5-dihydroxypyrimidine, orotic acid, 5-hydroxyuracil, adenine, 4-aminoimidazole-5-carboxamide and amino acids. These results, together with the earlier data, demonstrate that the three main classes of nitrogen-containing biomolecules, purines, pyrimidines and amino acids may have originated from HCN on the primitive earth. The observation of orotic acid and 4-aminoimidazole-5-carboxamide… CONTINUE READING
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    References

    SHOWING 1-10 OF 22 REFERENCES
    Synthesis of purines under possible primitive earth conditions. II. Purine intermediates from hydrogen cyanide.
    • 195
    Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide.
    • 299
    • PDF
    Uridin-5-oxy acetic acid: a new minor constituent from E. coli valine transfer RNA I.
    • 52
    Nucleotide Sequence of E. coli B tRNAVal1
    • 127
    A COLORIMETRIC DETERMINATION OF OROTIC ACID.
    • 79