HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.

@article{Yamin2016HCMVVB,
  title={HCMV vCXCL1 Binds Several Chemokine Receptors and Preferentially Attracts Neutrophils over NK Cells by Interacting with CXCR2.},
  author={Rachel Yamin and Laura S M Lecker and Yiska Weisblum and Alon Vitenshtein and Vu Thuy Khanh Le-Trilling and Dana G. Wolf and Ofer Mandelboim},
  journal={Cell reports},
  year={2016},
  volume={15 7},
  pages={1542-1553}
}
HCMV is a highly sophisticated virus that has developed various mechanisms for immune evasion and viral dissemination throughout the body (partially mediated by neutrophils). NK cells play an important role in elimination of HCMV-infected cells. Both neutrophils and NK cells utilize similar sets of chemokine receptors to traffic, to and from, various organs. However, the mechanisms by which HCMV attracts neutrophils and not NK cells are largely unknown. Here, we show a unique viral protein… CONTINUE READING
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