HBx represses RIZ1 expression by DNA methyltransferase 1 involvement in decreased miR-152 in hepatocellular carcinoma.

@article{Zhao2017HBxRR,
  title={HBx represses RIZ1 expression by DNA methyltransferase 1 involvement in decreased miR-152 in hepatocellular carcinoma.},
  author={Zhujiang Zhao and Ying Hu and Xiaohui Shen and Yingbin Lao and Lihua Zhang and Xuemei Qiu and Jiaojiao Hu and Pihai Gong and He Cui and Sen Lu and Ying Zheng and Menghan Zhou and Hong Fan},
  journal={Oncology reports},
  year={2017},
  volume={37 5},
  pages={
          2811-2818
        }
}
Hepatitis B virus (HBV) is mainly suspected to promote hepatocellular carcinoma (HCC) development by epigenetic alteration. The HBV X protein (HBx) plays a key role in the molecular pathogenesis of HBV-related HCC. However, the mechanism of HBx-mediated hepatocarcinogenesis remains to be elucidated. RIZ1 gene, a candidate HCC suppressor gene, is frequently found to be hypermethylated and downregulated in HCC. In the present study, we show that the expression of RIZ1 was downregulated in 65% HCC… CONTINUE READING

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