HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-kappaB.

@article{Xia2009HBxPI,
  title={HBx protein induces expression of MIG and increases migration of leukocytes through activation of NF-kappaB.},
  author={Li-min Xia and Wen-jie Huang and Jianguo Wu and Yong-bo Yang and Qiong Zhang and Zhen-Zhen Zhou and Hui-fen Zhu and Pin Lei and Guan-xin Shen and De-an Tian},
  journal={Virology},
  year={2009},
  volume={385 2},
  pages={
          335-42
        }
}
Elevated expression of monokine induced by the interferon-gamma (MIG) has been shown in HBV carriers, and it is involved in the infiltration of inflammatory cells and liver damage after HBV infection. However, the molecular mechanisms by which HBV-induced MIG expression have not been characterized. Our results indicated that HBx protein induced MIG expression in a dose-dependent manner. Such increase was due to the direct binding of NF-kappaB to the MIG promoter. By luciferase, chromatin… CONTINUE READING
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