HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line.

@article{Yang2009HBxPI,
  title={HBx protein induces EMT through c-Src activation in SMMC-7721 hepatoma cell line.},
  author={Shi Zhong Yang and Lei Zhang and Yi Zhang and Yan Xiong and Yu Jun Zhang and Hao Li and Xiao Wu Li and Jia Hong Dong},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={382 3},
  pages={555-60}
}
The relationships between epithelial-to-mesenchymal transition (EMT), hepatitis B virus X protein (HBx), and the non-receptor tyrosine kinase c-Src were investigated. The HBx gene transfected SMMC-7721 cells underwent morphological changes from a classic epithelial morphology to a spindle-like shape. The HBx transfection increased the invasive potential of these cells. When the transfected cells were exposed to the c-Src kinase inhibitor PP2, the cells recovered their original epithelial… CONTINUE READING

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