HBZ is an immunogenic protein, but not a target antigen for human T-cell leukemia virus type 1-specific cytotoxic T lymphocytes.

@article{Suemori2009HBZIA,
  title={HBZ is an immunogenic protein, but not a target antigen for human T-cell leukemia virus type 1-specific cytotoxic T lymphocytes.},
  author={Koichiro Suemori and Hiroshi Fujiwara and T. Ochi and T Ogawa and Masao Matsuoka and Tadashi Matsumoto and J E Mesnard and Masaki Yasukawa},
  journal={The Journal of general virology},
  year={2009},
  volume={90 Pt 8},
  pages={1806-11}
}
Recently, HBZ has been reported to play an important role in the proliferation of adult T-cell leukaemia (ATL) cells and might be a target of novel therapy for ATL. To develop a novel immunotherapy for ATL, we verified the feasibility of cellular immunotherapy targeting HBZ. We established an HBZ-specific and HLA-A*0201-restricted cytotoxic T lymphocyte (CTL) clone. Detailed study using this CTL clone clearly showed that HBZ is certainly an immunogenic protein recognizable by human CTLs… CONTINUE READING
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