HBV-specific peptide associated with heat-shock protein gp96

@article{Meng2001HBVspecificPA,
  title={HBV-specific peptide associated with heat-shock protein gp96},
  author={Shuangyan Meng and Ting Gao and George Fu Gao and Pham Trong Tien},
  journal={The Lancet},
  year={2001},
  volume={357},
  pages={528-529}
}
Glycoprotein 96 (gp96), a member of the heat-shock protein family, can elicit priming of antigen-specfic cytotoxic T lymphocytes, when bound to antigenic viral or tumour peptides. We used direct peptide isolation from purified gp96 and microsequencing to show that a virus-specific peptide is bound to gp96 derived from liver tissues of patients with hepatitis B virus (HBV)-induced hepatocellular carcinoma. This virus-specific peptide has potential for engineering tumour vaccines against… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

Similar Papers

Loading similar papers…