HBV-derived promoters direct liver-specific expression of an adenovirally transduced LDL receptor gene.

@article{Sandig1996HBVderivedPD,
  title={HBV-derived promoters direct liver-specific expression of an adenovirally transduced LDL receptor gene.},
  author={Volker Sandig and Peter L{\"o}ser and Andr{\'e} Lieber and Mark A. Kay and Michael Strauss},
  journal={Gene therapy},
  year={1996},
  volume={3 11},
  pages={1002-9}
}
In vivo approaches to liver gene therapy will require restriction of transgene expression to hepatocytes. Since targeting of viral vectors exclusively to the liver is not easy to achieve, use of liver-specific promoters for driving expression of therapeutic genes is an interesting alternative. We have shown previously that regulatory elements of the hepatotrophic hepatitis B virus (HBV) are strong and liver-specific in vitro and therefore might be useful in hepatic gene therapy. Here we… CONTINUE READING
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