HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B.

@article{Nassal2015HBVCV,
  title={HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B.},
  author={Michael Nassal},
  journal={Gut},
  year={2015},
  volume={64 12},
  pages={1972-84}
}
At least 250 million people worldwide are chronically infected with HBV, a small hepatotropic DNA virus that replicates through reverse transcription. Chronic infection greatly increases the risk for terminal liver disease. Current therapies rarely achieve a cure due to the refractory nature of an intracellular viral replication intermediate termed covalently closed circular (ccc) DNA. Upon infection, cccDNA is generated as a plasmid-like episome in the host cell nucleus from the protein-linked… CONTINUE READING
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