HB-EGF embedded in PGA/PLLA scaffolds via subcritical CO2 augments the production of tissue engineered intestine.

@article{Liu2016HBEGFEI,
  title={HB-EGF embedded in PGA/PLLA scaffolds via subcritical CO2 augments the production of tissue engineered intestine.},
  author={Yanchun Liu and Tyler Nelson and Barrett P Cromeens and Terrence M Rager and John J. Lannutti and Jacob Johnson and Gail E. Besner},
  journal={Biomaterials},
  year={2016},
  volume={103},
  pages={
          150-159
        }
}
The ability to deliver sustained-release, biologically active growth factors through custom designed tissue engineering scaffolds at sites of tissue regeneration offers great therapeutic opportunity. Due to the short in vivo half-lives of most growth factors, it is challenging to deliver these proteins to sites of interest where they may be used before being degraded. The application of subcritical CO2 uses gas-phase CO2 at subcritical pressures ranging from 41 to 62 bar (595-913 PSI) which… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 88 REFERENCES

A

C. L. Chen, X. Yu, I. O. James, H. Y. Zhang, J. Yang
  • Radulescu, et al., intestinal stem cells from injury in a rat model of necrotizing enterocolitis, Lab. Investig J. Tech. Methods Pathol. 92
  • 2012
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

N

C. L. Watson, M. M. Mahe, J. Munera, J. C. Howell
  • Sundaram, H.M. Poling, et al., An in vivo model of human small intestine using pluripotent stem cells, Nat. Med. 20
  • 2014
VIEW 1 EXCERPT

T

L. Boomer, Y. Liu, N. Mahler, J. Johnson, K. Zak
  • Nelson, et al., Scaffolding for Y. Liu et al. / Biomaterials 103 (2016) 150e159 159 challenging environments: materials selection for tissue engineered intestine, J. Biomed. Mater. Res. Part A 102
  • 2014