HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis.

@article{Zhang2012HAb18GCD147PA,
  title={HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis.},
  author={Dawei Zhang and You-Xu Zhao and Ding Ying Wei and Ya-lin Li and Yang Zhang and Jiao Wu and Jing Xu and Changsheng Chen and Hao Tang and Wei Zhang and L F Gong and Ying Han and Zhi-Nan Chen and Huijie Bian},
  journal={Journal of hepatology},
  year={2012},
  volume={57 6},
  pages={1283-91}
}
BACKGROUND & AIMS Activated hepatic stellate cells (HSCs) located in the Disse's space play a crucial role in liver fibrosis. HAb18G/CD147, a tumor-related glycoprotein, is highly expressed in hepatocellular carcinoma cells and fibroblasts. Whether HAb18G/CD147 plays an important role in the hepatic fibrogenesis is unknown. METHODS Immunohistochemistry for HAb18G/CD147 and α-smooth muscle actin expression in diseased liver tissues was used for correlation analysis. The function of HAb18G… CONTINUE READING

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