HAX-1 Promotes the Chemoresistance, Invasion, and Tumorigenicity of Esophageal Squamous Carcinoma Cells

@article{Sun2012HAX1PT,
  title={HAX-1 Promotes the Chemoresistance, Invasion, and Tumorigenicity of Esophageal Squamous Carcinoma Cells},
  author={Sa-jia Sun and Long Feng and Guoqiang Zhao and Zi-ming Dong},
  journal={Digestive Diseases and Sciences},
  year={2012},
  volume={57},
  pages={1838-1846}
}
HAX-1 is an anti-apoptotic factor and regulates the expression of DNA pol β. Interestingly, DNA polymerase pol β is overexpressed in esophageal squamous cell carcinoma (ESCC). However, the functional role of HAX-1 in ESCC remains unclear. To investigate the role of HAX-1 in chemoresistance, invasion, and tumorigenicity of ESCC. Lentivirus-mediated overexpression or knockdown of HAX-1 was employed to establish ESCC EC9706 cell lines that expressed HAX-1 at different levels. The biological… CONTINUE READING