HATs off for the Lasker awardees

  title={HATs off for the Lasker awardees},
  author={Paulina J. Strzyz},
  journal={Nature Reviews Molecular Cell Biology},
  • P. Strzyz
  • Published 19 September 2018
  • Biology
  • Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology congratulates the winners of the 2018 Lasker Foundation Awards. 


Splicing double: insights from the second spliceosome
Almost 20 years after the discovery of introns and RNA splicing, a second spliceosome was uncovered and mediates the excision of a minor class of evolutionarily conserved introns that have non-canonical consensus sequences.
Metabolic regulation of gene expression through histone acylations
A model is proposed to explain the present understanding of how differential histone acylation is regulated by the metabolism of the different acyl-CoA forms, which in turn modulates the regulation of gene expression.
Multivalent engagement of chromatin modifications by linked binding modules
It is proposed that multivalent interactions on a single histone tail and beyond may have a significant, if not dominant, role in chromatin transactions.
Genome-wide patterns of histone modifications in yeast
These experiments describe how combinations of modified and unmodified states relate to each other and particularly to chromosomal landmarks that include heterochromatin, subtelomeric chromatin, centromeres, origins of replication, promoters and coding regions.
Sydney Brenner
  • E. Friedberg
  • Biology
    Nature Reviews Molecular Cell Biology
  • 2008
Sydney Brenner won the nobel Prize in 2002 for establishing Caenorhabditis elegans as the widely used experimental model it is today.
Joan Steitz
Speaking of papers, how do you view the impact of the electronic age on the life sciences? Computers are not going to give us answers to hypothesis-driven questions. But the ability to store and