HARP is an ATP-driven annealing helicase.

@article{Yusufzai2008HARPIA,
  title={HARP is an ATP-driven annealing helicase.},
  author={Timur M. Yusufzai and James T. Kadonaga},
  journal={Science},
  year={2008},
  volume={322 5902},
  pages={748-50}
}
DNA-dependent adenosine triphosphatases (ATPases) participate in a broad range of biological processes including transcription, DNA repair, and chromatin dynamics. Mutations in the HepA-related protein (HARP) ATPase are responsible for Schimke immuno-osseous dysplasia (SIOD), but the function of the protein is unknown. We found that HARP is an ATP-dependent annealing helicase that rewinds single-stranded DNA bubbles that are stably bound by replication protein A. Other related ATPases… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 73 extracted citations

Targeting SMARCAL1 as a novel strategy for cancer therapy.

Biochemical and biophysical research communications • 2012
View 14 Excerpts
Highly Influenced

Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively

Nucleic acids research • 2017
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…