HARP is an ATP-driven annealing helicase.

  title={HARP is an ATP-driven annealing helicase.},
  author={Timur M. Yusufzai and James T. Kadonaga},
  volume={322 5902},
DNA-dependent adenosine triphosphatases (ATPases) participate in a broad range of biological processes including transcription, DNA repair, and chromatin dynamics. Mutations in the HepA-related protein (HARP) ATPase are responsible for Schimke immuno-osseous dysplasia (SIOD), but the function of the protein is unknown. We found that HARP is an ATP-dependent annealing helicase that rewinds single-stranded DNA bubbles that are stably bound by replication protein A. Other related ATPases… CONTINUE READING

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