HAPLO-ASP: Haplotype Inference Using Answer Set Programming


Identifying maternal and paternal inheritance is essential to be able to find the set of genes responsible for a particular disease. However, due to technological limitations, we have access to genotype data (genetic makeup of an individual), and determining haplotypes (genetic makeup of the parents) experimentally is a costly and time consuming procedure. With these biological motivations, we study haplotype inference—determining the haplotypes that form a given set of genotypes—using Answer Set Programming; we call our approach HAPLO-ASP. This note summarizes the range of problems that can be handled by HAPLO-ASP, and its applicability and effectiveness on real data in comparison with the other existing approaches.

DOI: 10.1007/978-3-642-04238-6_60

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@inproceedings{Erdem2009HAPLOASPHI, title={HAPLO-ASP: Haplotype Inference Using Answer Set Programming}, author={Esra Erdem and Ozan Erdem and Ferhan T{\"{u}re}, booktitle={LPNMR}, year={2009} }