HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons

Abstract

When BDNF binds to its receptors, TrkB and p75NTR, the BDNF-receptor complex is endocytosed and trafficked to the cell body for downstream signal transduction, which plays a critical role in neuronal functions. Huntingtin-associated protein 1 (HAP1) is involved in trafficking of vesicles intracellularly and also interacts with several membrane proteins… (More)
DOI: 10.1007/s12035-016-0379-0

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