HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle.

@article{Li2017HAND1LM,
  title={HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle.},
  author={Li Li and Juan Wang and Xingyuan Liu and Hua Liu and Hong-yu Shi and Xiao-xiao Yang and Ning Li and Yan-jie Li and Ri-Tai Huang and Song Xue and Xing-biao Qiu and Yi-Qing Yang},
  journal={International journal of molecular medicine},
  year={2017},
  volume={39 3},
  pages={711-718}
}
Congenital heart defects (CHDs), a wide variety of developmental abnormalities in the structures of the heart and the great thoracic blood vessels, are the most common form of birth defect in humans worldwide. CHDs are accountable for substantial morbidity and are still the leading cause of birth defect‑related deaths. Recent studies have demonstrated the pivotal roles of genetic defects in the pathogenesis of CHDs, and a great number of genetic mutations have been associated with CHDs… CONTINUE READING