HAND transcription factors are required for neonatal sympathetic neuron survival.

@article{Doxakis2008HANDTF,
  title={HAND transcription factors are required for neonatal sympathetic neuron survival.},
  author={Epaminondas Doxakis and Laura M. Howard and Hermann G. Rohrer and Alun M Davies},
  journal={EMBO reports},
  year={2008},
  volume={9 10},
  pages={
          1041-7
        }
}
Expression of the basic helix-loop-helix transcription factor HAND2 begins early in sympathetic neuron development and is essential for the differentiation of noradrenergic neurons. Here, we show that the expression of HAND2 and related HAND1 are maintained in sympathetic neurons throughout fetal and postnatal development when these neurons depend on target-derived nerve growth factor (NGF) for survival. Short interfering RNA knockdown of endogenous HAND2 and, to a lesser extent, HAND1 in… CONTINUE READING
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