HAMP Domain Conformers That Propagate Opposite Signals in Bacterial Chemoreceptors

@inproceedings{Airola2013HAMPDC,
  title={HAMP Domain Conformers That Propagate Opposite Signals in Bacterial Chemoreceptors},
  author={Michael V. Airola and Nattakan Sukomon and Dipanjan Samanta and Peter P. Borbat and Jack H. Freed and Kylie J Watts and Brian R Crane},
  booktitle={PLoS biology},
  year={2013}
}
HAMP domains are signal relay modules in >26,000 receptors of bacteria, eukaryotes, and archaea that mediate processes involved in chemotaxis, pathogenesis, and biofilm formation. We identify two HAMP conformations distinguished by a four- to two-helix packing transition at the C-termini that send opposing signals in bacterial chemoreceptors. Crystal structures of signal-locked mutants establish the observed structure-to-function relationships. Pulsed dipolar electron spin resonance… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 41 references

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Acta crystallographica. Section D, Biological crystallography • 2010
View 4 Excerpts
Highly Influenced

Signaling mechanisms of HAMP domains in chemoreceptors and sensor kinases.

Annual review of microbiology • 2010
View 4 Excerpts
Highly Influenced

Transmembrane signaling in bacterial chemoreceptors.

Trends in biochemical sciences • 2001
View 13 Excerpts
Highly Influenced

Coot: model-building tools for molecular graphics.

Acta crystallographica. Section D, Biological crystallography • 2004
View 2 Excerpts
Highly Influenced

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