HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment

  title={HAMLET Binding to α-Actinin Facilitates Tumor Cell Detachment},
  author={Maria Trulsson and Hao Yu and L Lennart Gisselsson and Yinxia Chao and Alexander Urbano and Sonja Aits and A Mossberg and Catharina Svanborg},
  booktitle={PloS one},
Cell adhesion is tightly regulated by specific molecular interactions and detachment from the extracellular matrix modifies proliferation and survival. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a protein-lipid complex with tumoricidal activity that also triggers tumor cell detachment in vitro and in vivo, suggesting that molecular interactions defining detachment are perturbed in cancer cells. To identify such interactions, cell membrane extracts were used in Far-western… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 59 references

Similar Papers

Loading similar papers…