HALVING OF MORTALITY OF SEVERE MELIOIDOSIS BY CEFTAZIDIME

@article{White1989HALVINGOM,
  title={HALVING OF MORTALITY OF SEVERE MELIOIDOSIS BY CEFTAZIDIME},
  author={N. White and W. Chaowagul and V. Wuthiekanun and D. Dance and Y. Wattanagoon and N. Pitakwatchara},
  journal={The Lancet},
  year={1989},
  volume={334},
  pages={697-701}
}
An open randomised trial was conducted to compare ceftazidime (120 mg/kg/day) with "conventional therapy" (chloramphenicol 100 mg/kg/day, doxycycline 4 mg/kg/day, trimethoprim 10 mg/kg/day, and sulphamethoxazole 50 mg/kg/day) in the treatment of severe melioidosis. A paired restricted sequential trial designed to detect a reduction in mortality from 80 to 40% in culture-positive patients surviving greater than 48 hours was stopped after 22 months. Of the 161 patients entered into the study, 65… Expand
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