[HAIR-AN syndrome].


Many clinical observations have suggested that there is a strong relationship between hyperinsulinemia and hyperandrogenism. HAIR-AN syndrome is defined as a constellation of hyperandrogenism (HA), insulin resistance (IR), and acanthosis nigricans (AN). Two major mechanisms could account for this syndrome: (i) hyperinsulinemia induced by insulin resistance causes hyperandrogenism, and (ii) hyperandrogenism causes insulin resistance and hyperinsulinemia. Acanthosis nigricans is considered to be an epiphenomenon caused by hyperinsulinemia. The causes of HAIR-AN syndrome include syndromes of extreme insulin resistance due to mutations in the insulin receptor gene, lipoatrophic diabetes, obesity, some endocrinopathies, and genetic and acquired ovarian hyperandrogenism.

Cite this paper

@article{Kadowaki1994HAIRANS, title={[HAIR-AN syndrome].}, author={Hiroko Kadowaki and Takashi Kadowaki}, journal={Nihon rinsho. Japanese journal of clinical medicine}, year={1994}, volume={52 10}, pages={2648-52} }