HAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasis

@article{Wu2019HAI2AA,
  title={HAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasis},
  author={Sr Wu and Chia-Hao Lin and Han-Po Shih and C. Y. Ko and Hsin-Ying Lin and Shao-Wei Lan and Hsin-Hsien Lin and Hsin-Fang Tu and Chao-Chi Ho and Hsiang-po Huang and Ming-Shyue Lee},
  journal={British Journal of Cancer},
  year={2019},
  volume={120},
  pages={499-511}
}
BackgroundDysregulation of pericellular proteolysis usually accounts for cancer cell invasion and metastasis. Isolation of a cell-surface protease system for lung cancer metastasis is an important issue for mechanistic studies and therapeutic target identification.MethodsImmunohistochemistry of a tissue array (n = 64) and TCGA database (n = 255) were employed to assess the correlation between serine protease inhibitors (SPIs) and lung adenocarcinoma progression. The role of SPI in cell motility… CONTINUE READING
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