HADDOCK: a protein-protein docking approach based on biochemical or biophysical information.

@article{Dominguez2003HADDOCKAP,
  title={HADDOCK: a protein-protein docking approach based on biochemical or biophysical information.},
  author={Cyril Dominguez and Rolf Boelens and Alexandre M. J. J. Bonvin},
  journal={Journal of the American Chemical Society},
  year={2003},
  volume={125 7},
  pages={
          1731-7
        }
}
The structure determination of protein-protein complexes is a rather tedious and lengthy process, by both NMR and X-ray crystallography. Several methods based on docking to study protein complexes have also been well developed over the past few years. Most of these approaches are not driven by experimental data but are based on a combination of energetics and shape complementarity. Here, we present an approach called HADDOCK (High Ambiguity Driven protein-protein Docking) that makes use of… CONTINUE READING
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