HAB/LAB rats: an animal model of extremes in trait anxiety and depression

@article{Landgraf2003HABLABRA,
  title={HAB/LAB rats: an animal model of extremes in trait anxiety and depression},
  author={Rainer Landgraf},
  journal={Clinical Neuroscience Research},
  year={2003},
  volume={3},
  pages={239-244}
}
Using an intra-strain, bidirectional selective breeding approach, Wistar rats were bred for either high (HAB) or low (LAB) anxiety-related behaviour on the elevated plus-maze and a variety of additional behavioural tests including black/white box, open field, modified hole board, social interaction and ultrasound vocalization. Increased adrenocorticotropic hormone (ACTH) and corticosterone secretion upon mild stressor exposure suggests a hyper-reactivity of the hypothalamo-pituitary… CONTINUE READING
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