HAART in HIV-infected patients: restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia.

@article{Wendland1999HAARTIH,
  title={HAART in HIV-infected patients: restoration of antigen-specific CD4 T-cell responses in vitro is correlated with CD4 memory T-cell reconstitution, whereas improvement in delayed type hypersensitivity is related to a decrease in viraemia.},
  author={Thomas Wendland and Hansjakob Furrer and Pietro Vernazza and Karin Frutig and Anna Christen and Lukas Matter and Raffaele Malinverni and Werner J Pichler},
  journal={AIDS},
  year={1999},
  volume={13 14},
  pages={
          1857-62
        }
}
OBJECTIVE To analyse prospectively the effect of highly active antiretroviral treatment (HAART) on CD4 T-cell responses in vitro and in vivo in HIV-infected patients. DESIGN Prospective study with 49 protease inhibitor-naive adult patients. Data were collected at baseline and after 3 and 6 months of HAART. METHODS In vitro CD4 T-cell reactivity was analysed by stimulation of peripheral blood mononuclear cells with several antigens. In vivo CD4 T-cell reactivity (delayed type… 
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Preliminary findings show that a low number of CD4+ T cells produce mycobacteria-specific effector cytokines in response to M.tuberculosis and M.avium antigens both in healthy individuals and HIV patients.
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Diverse functional features of HIV-specific CD4+ T cells suggest that they may exert direct antiviral activity in chronic HIV-1-infection.
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A beneficial effect on CNAR is suggested in those individuals with reduced activity, typically in late-stage infection, in patients at the intermediate and late stages of HIV infection.
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  • A. Shete, S. Dhayarkar, +6 authors R. Gangakhedkar
  • Medicine, Biology
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
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Decreased Activated CD4+ T Cell Repertoire Diversity After Antiretroviral Therapy in HIV-1/HCV Coinfection Correlates with CD4+ T Cell Recovery.
TLDR
Insight is provided into the dynamic relationship between activated CD4+ TCR diversity and CD4/HCV coinfected individuals after suppression of HIV-1 viremia and the association of decreased activation of T cell receptor sequences may represent loss of nonspecifically activated TCR clonotypes, and possibly selective expansion of specifically activatedCD4+ clones.
In vivo cell-mediated immunity in subjects with undetectable viral load on protease inhibitor-based versus non-protease inhibitor-based highly active antiretroviral therapy.
TLDR
The primary outcome was the summed DTH response, defined as the summation of induration in millimeters to each antigen divided by the number of antigens with induration, according to the current recommendation for the initiation of HAART.
Improvement of HIV-specific immunity in HIV-infected twins treated with highly active antiretroviral therapy, interleukin 2, and syngeneic adoptively transferred cells.
TLDR
Treatment consisting of HAART, adoptive cellular therapy, and IL-2 was superior to treatment with HAART alone for improving absolute and percent CD4(+) cell counts and inducing new, or increasing the magnitude of, HIV-specific immune responses in HIV infected patients.
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TLDR
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TLDR
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