H9N2 influenza whole inactivated virus combined with polyethyleneimine strongly enhances mucosal and systemic immunity after intranasal immunization in mice.

@article{Qin2015H9N2IW,
  title={H9N2 influenza whole inactivated virus combined with polyethyleneimine strongly enhances mucosal and systemic immunity after intranasal immunization in mice.},
  author={Tao Qin and Yinyan Yin and Lulu Huang and Qinghua Yu and Qian Yang},
  journal={Clinical and vaccine immunology : CVI},
  year={2015},
  volume={22 4},
  pages={421-9}
}
Influenza whole inactivated virus (WIV) is more immunogenic and induces protective antibody responses compared with other formulations, like split virus or subunit vaccines, after intranasal mucosal delivery. Polyethyleneimine (PEI), an organic polycation, is widely used as a reagent for gene transfection and DNA vaccine delivery. Although PEI recently has demonstrated potent mucosal adjuvant activity for viral subunit glycoprotein antigens, its immune activity with H9N2 WIV is not well… CONTINUE READING
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Volume 22 Number 4 Clinical and Vaccine Immunology on M ay 11

  • IM van der Lubben, G Kersten, MM Fretz, C Beuvery, J Coos Verhoef, Qin
  • Vaccine
  • 2015
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