H6phospa-trastuzumab: bifunctional methylenephosphonate-based chelator with 89Zr, 111In and 177Lu.

Abstract

The acyclic chelator H6phospa and the bifunctional derivative p-SCN-Bn-H6phospa have been synthesized using nosyl protection chemistry and evaluated with (89)Zr, (111)In, and (177)Lu. The p-SCN-Bn-H6phospa derivative was successfully conjugated to trastuzumab with isotopic dilution assays indicating 3.3 ± 0.1 chelates per antibody and in vitro cellular… (More)
DOI: 10.1039/c3dt51940f

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Cite this paper

@article{Price2014H6phospatrastuzumabBM, title={H6phospa-trastuzumab: bifunctional methylenephosphonate-based chelator with 89Zr, 111In and 177Lu.}, author={Eric W. Price and Brian M Zeglis and Jason S Lewis and Michael J. Adam and Chris Orvig}, journal={Dalton transactions}, year={2014}, volume={43 1}, pages={119-31} }