H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.

  title={H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.},
  author={Wouter van Rheenen and Frank P. Diekstra and Perry T C van Doormaal and Meinie Seelen and Kevin Patrick Kenna and Russell L McLaughlin and Aleksey Shatunov and D Czell and Michael A van Es and Paul W. J. van Vught and Philip Van Damme and Bradley N Smith and Stefan Waibel and Helenius Jurgen Schelhaas and Anneke Jelly van der Kooi and Marianne de Visser and Markus Weber and Wim Robberecht and Orla Hardiman and Pamela J Shaw and Christopher E. Shaw and Karen E. Morrison and Ammar Al-Chalabi and Peter Munch Andersen and Albert Christian Ludolph and Jan H Veldink and Leonard H van den Berg},
  journal={Neurobiology of aging},
  volume={34 5},
The H63D polymorphism in HFE has frequently been associated with susceptibility to amyotrophic lateral sclerosis (ALS). Regarding the role of HFE in iron homeostasis, iron accumulation is considered an important process in ALS. Furthermore, novel therapeutic strategies are being developed targeting this process. Evidence for this genetic association is, however, limited to several small studies. For this reason we studied the H63D polymorphism in a large European cohort including 3962 ALS… CONTINUE READING