H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.

@article{Yang2009H5N1SH,
  title={H5N1 strain-specific hemagglutinin CD4+ T cell epitopes restricted by HLA DR4.},
  author={Junbao Yang and John A. Gebe and Laurie Huston and Eddie A James and Venus Tan and Betty B. Yue and Gerald T Nepom and William W Kwok},
  journal={Vaccine},
  year={2009},
  volume={27 29},
  pages={3862-9}
}
CD4+ T cells play a pivotal role in the viral immunity, and as such identification of unique strain-specific HLA class II restricted epitopes is essential for monitoring cellular strain-specific viral immunity. Using Tetramer-Guided Epitope Mapping technique, we identified HLA-DR0401 restricted HA epitopes that are strain-specific to H5N1 virion. Two immunodominant epitopes H5HA(441-460) and H5HA(57-76) were identified from in vitro stimulated human PBMC. Both epitopes elicit strong cellular… CONTINUE READING