H5N1 Virus Activates Signaling Pathways in Human Endothelial Cells Resulting in a Specific Imbalanced Inflammatory Response

@article{Viemann2011H5N1VA,
  title={H5N1 Virus Activates Signaling Pathways in Human Endothelial Cells Resulting in a Specific Imbalanced Inflammatory Response},
  author={Dorothee Viemann and Mirco Schmolke and Aloys Lueken and Yvonne Boergeling and Judith Friesenhagen and Helmut Wittkowski and Stephan Ludwig and Johannes Roth},
  journal={The Journal of Immunology},
  year={2011},
  volume={186},
  pages={164 - 173}
}
H5N1 influenza virus infections in humans cause a characteristic systemic inflammatory response syndrome; however, the molecular mechanisms are largely unknown. Endothelial cells (ECs) play a pivotal role in hyperdynamic septic diseases. To unravel specific signaling networks activated by H5N1 we used a genome-wide comparative systems biology approach analyzing gene expression in human ECs infected with three different human and avian influenza strains of high and low pathogenicity. Blocking of… 

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