H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses

@inproceedings{Moris2010H5N1IV,
  title={H5N1 Influenza Vaccine Formulated with AS03A Induces Strong Cross-Reactive and Polyfunctional CD4 T-Cell Responses},
  author={Philippe J. Moris and Robbert G. van der Most and Isabel Leroux-Roels and Fr{\'e}d{\'e}ric Cl{\'e}ment and Mamadou Alioune Drame and Emmanuel Hanon and Geert G. Leroux-Roels and Marcelle Van Mechelen},
  booktitle={Journal of Clinical Immunology},
  year={2010}
}
ObjectiveAdjuvantation of an H5N1 split-virion influenza vaccine with AS03A substantially reduces the antigen dose required to produce a putatively protective humoral response and promotes cross-clade neutralizing responses. We determined the effect of adjuvantation on antibody persistence and B- and T-cell-mediated immune responses.MethodsTwo vaccinations with a split-virion A/Vietnam/1194/2004 (H5N1, clade 1) vaccine containing 3.75–30 μg hemagglutinin and formulated with or without adjuvant… CONTINUE READING
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