H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing

@article{Maksakova2011H3K9me3bindingPA,
  title={H3K9me3-binding proteins are dispensable for SETDB1/H3K9me3-dependent retroviral silencing},
  author={I. A. Maksakova and P. Goyal and J. Bullwinkel and Jeremy P. Brown and M. Bilenky and D. Mager and Prim B. Singh and M. Lorincz},
  journal={Epigenetics \& Chromatin},
  year={2011},
  volume={4},
  pages={12 - 12}
}
BackgroundEndogenous retroviruses (ERVs) are parasitic sequences whose derepression is associated with cancer and genomic instability. Many ERV families are silenced in mouse embryonic stem cells (mESCs) via SETDB1-deposited trimethylated lysine 9 of histone 3 (H3K9me3), but the mechanism of H3K9me3-dependent repression remains unknown. Multiple proteins, including members of the heterochromatin protein 1 (HP1) family, bind H3K9me2/3 and are involved in transcriptional silencing in model… Expand
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