H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs

@article{Chen2013H3K9MI,
  title={H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs},
  author={Jiekai Chen and He Liu and Jing Liu and Jing Qi and Bei Wei and Jiaqi Yang and Hanquan Liang and You Hua Chen and Jing Chen and Yaran Wu and Lin Guo and Jieying Zhu and Xiangjie Zhao and Tianran Peng and Yixin Zhang and Shen Chen and Xuejia Li and Dongwei Li and Tao Wang and Duanqing Pei},
  journal={Nature Genetics},
  year={2013},
  volume={45},
  pages={34-42}
}
The induction of pluripotent stem cells (iPSCs) by defined factors is poorly understood stepwise. Here, we show that histone H3 lysine 9 (H3K9) methylation is the primary epigenetic determinant for the intermediate pre-iPSC state, and its removal leads to fully reprogrammed iPSCs. We generated a panel of stable pre-iPSCs that exhibit pluripotent properties but do not activate the core pluripotency network, although they remain sensitive to vitamin C for conversion into iPSCs. Bone morphogenetic… CONTINUE READING
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