H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells.

@article{Hezroni2011H3K9HA,
  title={H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells.},
  author={Hadas Hezroni and Itai Tzchori and Anna Davidi and Anna Mattout and Alva Biran and Malka Nissim-Rafinia and Heiner Westphal and Eran Meshorer},
  journal={Nucleus},
  year={2011},
  volume={2 4},
  pages={300-9}
}
The pluripotent genome is characterized by unique epigenetic features and a decondensed chromatin conformation. However, the relationship between epigenetic regulation and pluripotency is not altogether clear. Here, using an enhanced MEF/ESC fusion protocol, we compared the reprogramming potency and histone modifications of different embryonic stem cell (ESC) lines (R1, J1, E14, C57BL/6) and found that E14 ESCs are significantly less potent, with significantly reduced H3K9ac levels. Treatment… CONTINUE READING

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