H3K27me3 immunohistochemistry highlights the inactivated X chromosome (Xi) and predicts sex in non-neoplastic tissues.

Abstract

Sir: Histone 3 trimethylation at lysine 27 (H3K27me3) represents a crucial epigenetic silencing mark and is detectable by immunohistochemistry. Mutations in the polycomb group proteins SUZ12 or EED, observed in approximately 80% of malignant peripheral nerve sheath tumours (MPNST), lead to inactivation of the polycomb repressive complex 2 (PRC2) and… (More)
DOI: 10.1111/his.12972

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