H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro

@inproceedings{Vanhove2016H3K27me3DN,
  title={H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro},
  author={Jolien Vanhove and Mariaelena Pistoni and Marc Welters and Kristel Eggermont and Veerle Vanslembrouck and Nicky Helsen and Ruben Boon and Mustapha Najimi and Etienne Sokal and Philippe Collas and Jan Willem Voncken and Catherine M. Verfaillie},
  booktitle={Stem cell reports},
  year={2016}
}
Although pluripotent stem cells can be differentiated into the hepatocyte lineages, such cells retain an immature phenotype. As the chromatin state of regulatory regions controls spatiotemporal gene expression during development, we evaluated changes in epigenetic histone marks in lineage-specific genes throughout in vitro hepatocyte differentiation from human embryonic stem cells (hESCs). Active acetylation and methylation marks at promoters and enhancers correlated with progressive changes in… CONTINUE READING