H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.

@article{Cui2004H3DO,
  title={H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 nucleotide-binding folds-1 and -2.},
  author={Ningren Cui and Youhou Kang and Yan He and Yuk-Man Leung and Huanli Xie and Ewa A. Pasyk and Xiaodong Gao and Laura Sheu and John Bondo Hansen and Philip Wahl and Robert G. Tsushima and Herbert Y Gaisano},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 51},
  pages={53259-65}
}
The ATP-sensitive potassium (K(ATP)) channel in pancreatic islet beta cells consists of four pore-forming (Kir6.2) subunits and four regulatory sulfonylurea receptor (SUR1) subunits. In beta cells, the K(ATP) channel links intracellular metabolism to the dynamic regulation of the cell membrane potential that triggers insulin secretion. Syntaxin 1A (Syn-1A) is a SNARE protein that not only plays a direct role in exocytosis, but also binds and modulates voltage-gated K(+) and Ca(2+) channels to… CONTINUE READING

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