H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis.

@article{Wang2016H3TP,
  title={H3 Thr3 phosphorylation is crucial for meiotic resumption and anaphase onset in oocyte meiosis.},
  author={Qian Wang and Haojie Wei and Juan Du and Yan Cao and Nana Zhang and Xiaoyun Liu and Xiaoyu Liu and Dandan Chen and W. T. Ma},
  journal={Cell cycle},
  year={2016},
  volume={15 2},
  pages={213-24}
}
Haspin-catalyzed histone H3 threonine 3 (Thr3) phosphorylation facilitates chromosomal passenger complex (CPC) docking at centromeres, regulating indirectly chromosome behavior during somatic mitosis. It is not fully known about the expression and function of H3 with phosphorylated Thr3 (H3T3-P) during meiosis in oocytes. In this study, we investigated the expression and sub-cellular distribution of H3T3-P, as well as its function in mouse oocytes during meiotic division. Western blot analysis… CONTINUE READING