H2S signalling through protein sulfhydration and beyond

  title={H2S signalling through protein sulfhydration and beyond},
  author={Bindu D Paul and Solomon H Snyder},
  journal={Nature Reviews Molecular Cell Biology},
Hydrogen sulfide (H2S) has recently emerged as a mammalian gaseous messenger molecule, akin to nitric oxide and carbon monoxide. H2S is predominantly formed from Cys or its derivatives by the enzymes cystathionine β-synthase and cystathionine γ-lyase. One of the mechanisms by which H2S signals is by sulfhydration of reactive Cys residues in target proteins. Although analogous to protein nitrosylation, sulfhydration is substantially more prevalent and usually increases the catalytic activity of… CONTINUE READING
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