H2S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation.

@article{Lu2017H2SIA,
  title={H2S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation.},
  author={Guihua Lu and Chenggui Xu and Kaiyu Tang and Juhong Zhang and Qinglang Li and Longyun Peng and Yesong Wang and Zhibin Huang and Xiu-ren Gao},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={483 1},
  pages={
          534-540
        }
}
Our previous study demonstrated that angiotensin II (Ang II) upregulates the expression of Kv1.5, a promising target for atrial fibrillation (AF) therapy, by activating ROS-dependent P-Smad2/3 and P-ERK 1/2. A recent study showed that hydrogen sulfide (H2S) may modulate the effects of angiotensin II (Ang II) by inhibiting the NADPH oxidase 4 (Nox4)-ROS signaling in the heart. The present study aimed to determine whether H2S is involved in the regulation of atrial Kv1.5 via ROS-related… CONTINUE READING
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