H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

@inproceedings{Eberhardt2014H2SAN,
  title={H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway},
  author={Mirjam Eberhardt and Maria Dux and Barbara Namer and Jan Lj. Miljkovic and Nada Cordasic and Christine Will and Tatjana I Kichko and Jeanne de la Roche and Michael J M Fischer and Sebastian A Suarez and Dam{\'i}an E Bikiel and Karola Dorsch and Andreas Leffler and Alexandru Babes and Angelika Lampert and Jochen K Lennerz and Johannes Jacobi and Marcelo A. Marti and Fabio Doctorovich and Edward D H{\"o}gest{\"a}tt and Peter M Zygmunt and Ivana Ivanovi{\'c}-Burmazovi{\'c} and Karl Messlinger and Peter W Reeh and Milos R Filipovic},
  booktitle={Nature communications},
  year={2014}
}
Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints of high significance in the treatment of heart failure. Beneficial HNO effects depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an unidentified mechanism. Here we propose that HNO is generated as a result of the reaction of the two gasotransmitters NO and H2S. We show that H2S and NO production colocalizes with transient… CONTINUE READING
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