H2S and HS− donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells

@article{Ondrias2008H2SAH,
  title={H2S and HS− donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells},
  author={Karol Ondrias and Andrej Sta{\vs}ko and Sona Cacanyiova and Zdena Sulov{\'a} and Oľga Kri{\vz}anov{\'a} and Franti{\vs}ek Kristek and Lubica Malekova and Vladim{\'i}r Knezl and Albert Breier},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2008},
  volume={457},
  pages={271-279}
}
Nitrosoglutathione [(GSNO), 500 nmol/l] relaxed the norepinephrine precontracted rat aortic rings. The relaxation effect was pronouncedly enhanced by H2S- and HS−-donor NaHS (30 μmol/l) at 7.5 pH but not at 6.3 pH. To study molecular mechanism of this effect, we investigated whether NaHS can release NO from NO donors. Using an electron paramagnetic resonance spectroscopy method of spin trap and by measuring the NO oxidation product, which is nitrite, by the Griess reaction, we report that NaHS… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed.

Physiological reviews • 2012
View 20 Excerpts
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View 1 Excerpt

Intracolonic hydrogen sulfide lowers blood pressure in rats.

Nitric oxide : biology and chemistry • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 42 references

H(2)S-induced vasorelaxation and underlying cellular and molecular mechanisms.

American journal of physiology. Heart and circulatory physiology • 2002
View 12 Excerpts
Highly Influenced

Evidence for the formation of a novel Pflugers Arch

M Whiteman, L Li, +4 authors PK Moore
Eur J Physiol • 2006
View 4 Excerpts
Highly Influenced

The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide.

Biochemical and biophysical research communications • 1997
View 5 Excerpts
Highly Influenced

H2S and cellular proliferation and apoptosis

Yang G-D, R Wang
Acta Physiol Sin • 2007
View 2 Excerpts

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