H2O2-induced chloride currents are indicative of an endogenous Na(+)-Ca2+ exchange mechanism in Xenopus oocytes.

@article{Schlief1995H2O2inducedCC,
  title={H2O2-induced chloride currents are indicative of an endogenous Na(+)-Ca2+ exchange mechanism in Xenopus oocytes.},
  author={Thomas Schlief and Stefan H. Heinemann},
  journal={The Journal of physiology},
  year={1995},
  volume={486 ( Pt 1)},
  pages={123-30}
}
1. Defolliculated Xenopus oocytes were voltage clamped in bathing solutions containing 115 mM KCl and 1.8 mM CaCl2. External application of H2O2 transiently elicited voltage-dependent outward rectifying currents within several seconds. Upon depolarization to +50 mV these currents had an activation time constant of 370 ms and reached amplitudes of up to 70 microA. This current was also observed in oocytes without the vitelline membrane. 2. The current was abolished by 500 microM niflumic acid… CONTINUE READING