H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.

@article{Tamagno2003H2O2A4,
  title={H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.},
  author={Elena Tamagno and Gaia Robino and Alessandra Obbili and Paola Bardini and Manuela Aragno and Maurizio Parola and Oliviero Danni},
  journal={Experimental neurology},
  year={2003},
  volume={180 2},
  pages={144-55}
}
Amyloid beta peptides (Abeta) may be neurotoxic during the progression of Alzheimer's disease by eliciting oxidative stress. Exposure of neuronally differentiated SK-N-BE cells to Abeta(25-35) fragment as well as to full-length Abeta(1-40) and Abeta(1-42) induces early and time-dependent generation of oxidative stress that has been evaluated by carefully monitoring generation of hydrogen peroxide (H(2)O(2)), 4-hydroxynonenal (HNE), thiobarbituric acid reactive substances (TBARS), and… CONTINUE READING
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