H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts.

@article{Colston2005H2O2AN,
  title={H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts.},
  author={James T. Colston and Sam D de la Rosa and James R Strader and Matthew A Anderson and Gregory L. Freeman},
  journal={FEBS letters},
  year={2005},
  volume={579 11},
  pages={2533-40}
}
Stimulated production of reactive oxygen species (ROS) by plasma membrane-associated nicotinamide adenine dinucleotide phosphate oxidases (Nox) in non-phagocytic cells regulates a number of biological processes including growth, vessel tone, and oxygen sensing. The purpose of this study was to investigate H(2)O(2)-stimulated ROS production in primary adult cardiac fibroblasts (CF). Results demonstrate that CF express an H(2)O(2)-inducible oxidant generating system that is inhibitable by… CONTINUE READING

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