H2O2 activates G protein, α 12 to disrupt the junctional complex and enhance ischemia reperfusion injury.

Abstract

The epithelial cell tight junction separates apical and basolateral domains and is essential for barrier function. Disruption of the tight junction is a hallmark of epithelial cell damage and can lead to end organ damage including renal failure. Herein, we identify Gα12 activation by H(2)O(2) leading to tight junction disruption and demonstrate a critical… (More)
DOI: 10.1073/pnas.1116800109

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